In a mixing bowl, combine ground beef with garlic powder, onion powder, salt, and pepper. Divide the meat into two equal portions and shape each into a patty.

Heat a skillet over medium-high heat, adding oil or butter to create a non-stick surface.

Place one beef patty on the skillet, top with a tortilla, and gently smash the beef into the tortilla. Cook for 2-3 minutes until browned.

Flip the quesadilla and sprinkle cheese over the beef. Fold the tortilla over and cook until the cheese melts.

Press the quesadilla gently and cook for 1-2 minutes until golden brown. Slice and serve with toppings.